硫酸钠溶解度
[摘要] 目的：建立HPLC法测定匹可硫酸钠片中匹可硫酸钠的含量。方法：采用高效液相色谱法，选用C18色谱柱，以磷酸盐缓冲液（pH值7.0）-乙腈（75∶25）为流动相，流速 1.0 ml/min，检测波长263 nm，进样量20 μl，柱温25℃。结果：匹可硫酸钠在溶液浓度为0.06~0.14 mg/ml之间时，线性关系良好（r=0.999 8）。低 、中、高浓度的平均回收率为99.53％，RSD为0.24％（n=9）。
结论：该方法快速简便，准确，重复性好，可用于匹可硫酸钠片的含量测定。
[关键词] 匹可硫酸钠；片剂；高效液相色谱法；含量测定
[中图分类号] R971[文献标识码]A[文章编号]1673-7210

（2011）03（c）-029-02

Determination of sodium picosulfate in the Sodium Picosulfate Tablets by HPLC
ZHU Guofeng
Furen Pharmaceutical Group Co. Ltd, Luyi477200, China
[Abstract] Objective: To establish an HPLC method for the determination of sodium picosulfate in the Sodium Picosulfate Tablets. Methods: HPLC was employed by using C18 as the column and phosphate buffer（pH=7.0）-acetonitrile（75∶25） as the mobile phase. Flow rate was 1.0 ml/min; the detection wavelength was 263 nm and the column temperature was 25℃; Sample volume was 20 μl. Results: A good linearity for sodium picosulfate was obtained in the range from 0.06-0.14 mg/ml (r=0.999 8). The average recoveries of low, medium and high concentrations was 99.53%, with RSD 0.24% (n= 9). Conclusion: The method is simple and fast, the results are accurate and reproducible for the determination of the Sodium Picosulfate Tablets.。

Tags：